Archive for August, 2014
Tai Chi-based exercise program provided via telerehabilitation compared to home visits in a post-stroke population who have returned home without intensive rehabilitation
…This study will verify the non-inferiority of in-home telerehabilitation compared to home visits for patients with mild to moderate balance problems post-stroke. Our hypothesis is that in-home telerehabilitation will be shown to be a good alternative to ensure continuity of rehabilitation services and their accessibility in the community…
μέσω Trials | Full text | Tai Chi-based exercise program provided via telerehabilitation compared to home visits in a post-stroke population who have returned home without intensive rehabilitation: study protocol for a randomized, non-inferiority clinical trial.
…Young children exposed to epilepsy drugs in the womb are at increased risk of having impaired fine motor skills, according to a new study. Exposure to the drugs in breast milk, however, does not appear to pose a threat…
…If an epilepsy patient and their doctor feel that marijuana is their best treatment option then they need to have safe, legal access to medical marijuana and they need that access now…
…Predicting motor recovery after stroke in individual patients is difficult. Accurate prognosis would enable realistic rehabilitation goal-setting and more efficient allocation of resources. The aim of this study was to test and refine an algorithm for predicting the potential for recovery of upper limb function after stroke…
…Besides conventional rehabilitation interventions and the most recent neuropharmacological approaches, non-invasive brain stimulation (NIBS) has recently been proposed as an add-on method to promote motor function recovery after stroke…
…Therefore, there is an urgent need for devising an effective long-term care and rehabilitation strategy for stroke patients, which would actively involve patients in the rehabilitation process while minimizing costly human support…
…Innovative technologies for sensorimotor rehabilitation after stroke have dramatically increased these past 20 years. Based on a review of the literature on “Medline” and “Web of Science” between 1990 and 2013, we offer an overview of available tools and their current level of validation…
[ARTICLE] Reach-to-grasp training in individuals with chronic stroke augmented by low-frequency repetitive transcranial magnetic stimulation
|OBJECTIVE: The present study investigated the immediate effects of low frequency repetitive transcranial magnetic stimulation (LF-rTMS) combined with reach-to-grasp (RTG) training of the paretic hand in individuals with chronic stroke.
MATERIAL AND METHOD: Fourteen participants were randomly assigned to receive LF-rTMS or sham stimulation conditions. All participants underwent RTG training after the stimulation. Corticospinal excitability (CE) of the non-lesioned hemisphere, the total time of the wolf motor function test (WMFT) for dexterity tasks, maximum aperture, and movement time of RTG actions were evaluated at baseline, after the stimulation, and after RTG training.
RESULTS: Significant differences between interaction (group x time) were found in the total time of WMFT The CE of non-lesioned hemisphere diminished after LF-rTMS and showed moderate correlation with the reduction in time of RTG actions after the stimulation. The total time of WMFT and RTG actions reduced after motor training only in the LF-rTMS group. No change was observed in maximum aperture in either group.
CONCLUSION: The application of LF-rTMS combined with RTG training enhanced the training effect as evidenced by faster movement for the dexterity tasks of the paretic hand than RTG training alone. The findings suggested the benefit of LF-rTMS for enhancing the training effects in stroke rehabilitation.
[ARTICLE] Combining enriched environment and induced pluripotent stem cell therapy results in improved cognitive and motor function following traumatic brain injury.
Despite advances towards potential clinically viable therapies there has been only limited success in improving functional recovery following traumatic brain injury (TBI). In rats, exposure to an enriched environment (EE) improves learning and fosters motor skill development. Induced pluripotent stem cells (iPSC) have been shown to survive transplantation and influence the recovery process. The current study evaluated EE and iPSC as a polytherapy for remediating cognitive deficits following medial frontal cortex (mFC) controlled cortical impact (CCI) injury.
Sixty adult male rats received a midline mFC CCI or sham injury and were randomly placed in either EE or standard environment (SE). Seven days post-injury rats received bilateral transplantation of iPSCs or media. Behavioral measures were conducted throughout the remainder of the study. Following behavioral analysis, brains were extracted and prepared for histological analysis.
Open-field data revealed that combined therapy resulted in typical Sham/EE activity rearing patterns by the conclusion of the study. On the Vermicelli Handling task, rats with EE/iPSC polytherapy performed better than media-treated rats. Furthermore, rats treated with polytherapy performed equivalently to Sham/EE rats on the Morris water maze. Proficiency on the Rotarod was consistently better in EE when compared to SE counterparts. Confocal microscopy confirmed that iPSCs survived and migrated away from the transplantation site.
Overall, EE or iPSC therapy improved cognition and motor performance, however, full cognitive restoration was seen only with the EE/iPSC treatment. These data suggest that EE/iPSC therapy should be explored as a potential, clinically relevant, treatment for TBI.
…Much of the stigma associated with the condition could be alleviated if people could anticipate their seizures and take necessary steps to make themselves safe, and modify their environment. Conceivably having accurate seizure prediction strategies could also permit administration of acutely acting anticonvulsant therapies. Seizure prediction systems may allow new insights into the natural history of the condition, and associated co-morbidities…