[WEB SITE] Research Reports – Study evaluating the effects of Cerebrolysin treatment on clinical outcomes in traumatic brain injury

Traumatic brain injury (TBI) is a leading cause of death and disability for which

there is currently no effective drug therapy available. Because drugs targeting a

single TBI pathological pathway have failed to show clinical efficacy to date,

pleiotropic agents with effects on multiple mechanisms of secondary brain damage

could represent an effective option to improve brain recovery and clinical

outcome in TBI patients. In this multicenter retrospective study, we investigated

severity-related efficacy and safety of the add-on therapy with two

concentrations (20 ml/day or 30 ml/day) of Cerebrolysin (EVER Neuro Pharma,

Austria) in TBI patients. Adjunctive treatment with Cerrebrolysin started within

48 hours after TBI and clinical outcomes were ranked according to the Glasgow

Outcome Scale and the Modified Rankin Disability Score at 10 and 30 days

post-TBI. Analyses of efficacy were performed separately for subgroups of

patients with mild, moderate or severe TBI according to Glasgow Coma Scale scores

at admission. Compared to standard medical care alone (control group), both doses

of Cerebrolysin were associated with improved clinical outcome scores at 10 days

post-TBI in mild patients and at 10 and 30 days in moderate and severe cases. A

dose-dependent effect of Cerebrolysin on TBI recovery was supported by the

dose-related differences and the significant correlations with treatment duration

observed for outcome measures. The safety and tolerability of Cerebrolysin in TBI

patients was very good. In conclusion, the results of this large retrospective

study revealed that early Cerebrolysin treatment is safe and is associated to

improved TBI outcome.

via Traumatic Brain Injury Resource Guide – Research Reports – Study evaluating the effects of Cerebrolysin treatment on clinical outcomes in traumatic brain injury.

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