[Abstract] “Genetic Variation and Neuroplasticity: Role in Rehabilitation after Stroke”

Provisional Abstract:

Background and Purpose: Significant inter-individual variability in rehabilitation outcomes exits in many neurologic diagnoses. One factor that may impact response to rehabilitation interventions is genetic variation. Genetic variation refers to the presence of differences in the DNA sequence among a population. Genetic polymorphisms are variations that occur relatively commonly and, while not disease causing, can impact the function of biological systems. The purpose of this article is to describe genetic polymorphisms that may impact neuroplasticity, learning and recovery after stroke.

Summary of Key Points: Genetic polymorphisms for brain-derived neurotrophic factor (BDNF), dopamine, and apolipoprotein E have been shown to impact neuroplasticity and motor learning. Rehabilitation interventions that rely on the molecular and cellular pathways of these factors may be impacted by the presence of the polymorphism. For example, it has been hypothesized that individuals with the BDNF polymorphism may show a decreased response to neuroplasticity based interventions, decreased rate of learning, and overall less recovery after stroke. However, research to date has been limited and additional work is needed to fully understand the role of genetic variation in learning and recovery.

Recommendations for Clinical Practice: Genetic polymorphisms should be considered as possible predictors or covariates in studies that investigate neuroplasticity, motor learning, or motor recovery after stroke. Future predictive models of stroke recovery will likely include a combination of genetic factors and other traditional factors (e.g. age, corticospinal tract integrity) to determine an individual’s expected response to a specific rehabilitation intervention.

Want to read the published article?
To be alerted when this article is published, please sign up for the Journal of Neurologic Physical Therapy eTOC.

Source: JUST ACCEPTED: “Genetic Variation and Neuroplasticity: Role in Rehabilitation after Stroke”

Advertisements

, , , , , ,

  1. Leave a comment

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: