Stroke remains one of the leading causes of long-term disability in both developed and developing countries. Prevalence and impact of the stroke-related disability on Health-Related Quality of Life (HRQoL) as a recognized and important outcome after stroke is huge. Quick, valid and reliable assessment of the HRQoL in people after stroke constitutes a significant worldwide problem for scientists and clinicians – there are many tools, but no one fulfills all requirements or has prevailing advantages. This paper presents proposition of an evaluation of HRQoL based on the two-level hierarchical fuzzy system. It uses five clinical scores and scales as the inputs and gives in result value from the interval [0; 1]. It may constitute a useful semi-automated tool for supplementary initial assessment of patient functioning and further cyclic re-assessment for rehabilitation process and patient-centered goals of rehabilitation shaping purposes.