[ARTICLE] Objective assessment of cortical activity changes in stroke patients before and after hand rehabilitation with and without botulinum toxin injection – Full Text

Abstract

Background Upper limb spasticity is a disabling condition and may result in severe functional limitation. The peripheral action of botulinum toxin (BTX) injection on spasticity is well known, but there are debates around its possible central action.
Aim The aim of this study was to assess the clinical, functional, and cortical activation outcome of two antispastic treatments for stroke of the hand and wrist. Thirty patients with upper limb poststroke spasticity were recruited in this study.
Patients and methods They were randomly allocated to two groups: group A and group B. Both groups received rehabilitation program, whereas group B received additional BTX injection. All patients were assessed at baseline and 8 weeks after treatment using the Modified Ashworth Scale, the Action Research Arm Test and Nine-Hole Peg Test, and somatosensory-evoked potential study of the median nerve.
Results Group B showed a higher percentage of change in Modified Ashworth Scale of the wrist flexors and long flexors of fingers and in Action Research Arm Test compared with group A.
Conclusion BTX injection in spastic muscles of the wrist and hand, followed by a rehabilitation program led to greater clinical and functional improvement compared with implementing the rehabilitation program alone.

Introduction

Upper limb spasticity can be disabling and can result in several functional limitations. Although some neural plasticity following stroke contributes to motor recovery, maladaptive plasticity can weaken motor function and limits the recovery. Spasticity represents an example of maladaptive plasticity [1].

Local injection of botulinum toxin-A (BTX) is the standard treatment for spasticity, particularly in poststroke patients. In addition to its peripheral action, evidence of its possible effects on central nervous systems has emerged [1].

Somatosensory-evoked potential (SEP) studies in patients with spasticity showed improvement in SEP following BTX injection, which may support the possible central action of BTX in the cerebral cortex [2],[3].[…]

Continue —> Objective assessment of cortical activity changes in stroke patients before and after hand rehabilitation with and without botulinum toxin injection Abu-Bakr OA, Nassar NM, Al-Ganzoury AM, Ahmed KA, Tawfik EA – Egypt Rheumatol Rehabil