[Abstract+References] Transcutaneous electrical nerve stimulation improves walking capacity and reduces spasticity in stroke survivors: a systematic review and meta-analysis

To evaluate (1) the effectiveness of transcutaneous electrical nerve stimulation (TENS) at improving lower extremity motor recovery in stroke survivors and (2) the optimal stimulation parameters for TENS.

A systematic search was conducted for studies published up to October 2017 using eight electronic databases (CINAHL, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PEDro, PubMed and Web of Science). Randomized controlled trials that evaluated the effectiveness of the application of TENS at improving lower extremity motor recovery in stroke survivors were assessed for inclusion. Outcomes of interest included plantar flexor spasticity, muscle strength, walking capacity and balance.

In all, 11 studies met the inclusion criteria which involved 439 stroke survivors. The meta-analysis showed that TENS improved walking capacity, as measured by either gait speed or the Timed Up and Go Test (Hedges’ g = 0.392; 95% confidence interval (CI) = 0.178 to 0.606) compared to the placebo or no-treatment control groups. TENS also reduced paretic plantar flexor spasticity, as measured using the Modified Ashworth Scale and Composite Spasticity Scale (Hedges’ g = –0.884; 95% CI = –1.140 to −0.625). The effect of TENS on walking capacity in studies involving 60 minutes per sessions was significant (Hedges’ g = 0.468; 95% CI = 0.201–0.734) but not in study with shorter sessions (20 or 30 minutes) (Hedges’ g = 0.254; 95% CI = –0.106–0.614).

The results support the use of repeated applications of TENS as an adjunct therapy for improving walking capacity and reducing spasticity in stroke survivors.

1. Levin, MF, Huichan, CWY. Relief of hemiparetic spasticity by TENS is associated with improvement in reflex and voluntary motor functions. Electroencephalogr Clin Neurophysiol 1992; 85(2): 131142Google ScholarCrossrefMedline
2. Chen, SC, Chen, YL, Chen, CJ. Effects of surface electrical stimulation on the muscle-tendon junction of spastic gastrocnemius in stroke patients. Disabil Rehabil 2005; 27(3): 105110Google ScholarCrossrefMedline
3. Cho, HY, In, TS, Cho, KH. A single trial of transcutaneous electrical nerve stimulation (TENS) improves spasticity and balance in patients with chronic stroke. Tohoku J Exp Med 2013; 229(3): 187193Google ScholarCrossrefMedline
4. Karakoyun, A, Boyraz, I, Gunduz, R. Electrophysiological and clinical evaluation of the effects of transcutaneous electrical nerve stimulation on the spasticity in the hemiplegic stroke patients. J Phys Ther Sci 2015; 27(11): 34073411Google ScholarCrossrefMedline
5. Martins, FL, Carvalho, LC, Silva, CC. Immediate effects of TENS and cryotherapy in the reflex excitability and voluntary activity in hemiparetic subjects: a randomized crossover trial. Rev Bras Fisioter 2012; 16(4): 337344http://onlinelibrary.wiley.com/o/cochrane/clcentral/articles/844/CN-00869844/frame.html Google Scholar
6. Sonde, L, Kalimo, H, Viitanen, M. Stimulation with high-frequency TENS-Effects on lower limb spasticity after stroke. Adv Physiother 2000; 2(4): 183187Google ScholarCrossref
7. Yan, T, Hui-Chan, CW. Transcutaneous electrical stimulation on acupuncture points improves muscle function in subjects after acute stroke: a randomized controlled trial. J Rehabil Med 2009; 41(5): 312316Google ScholarCrossrefMedline
8. Tyson, SF, Sadeghi-Demneh, E, Nester, CJ. The effects of transcutaneous electrical nerve stimulation on strength, proprioception, balance and mobility in people with stroke: a randomized controlled cross-over trial. Clin Rehabil 2013; 27(9): 785791Google ScholarLink
9. Hussain, T, Mohammad, H. The effect of transcutaneous electrical nerve stimulation (TENS) combined with Bobath on post stroke spasticity. A randomized controlled study. J Neurol Sci 2013; 333: e560Google ScholarCrossref
10. Ng, SS, Hui-Chan, CW. Does the use of TENS increase the effectiveness of exercise for improving walking after stroke? A randomized controlled clinical trial. Clin Rehabil 2009; 23(12): 10931103Google ScholarLink
11. Ng, SS, Hui-Chan, CW. Transcutaneous electrical nerve stimulation combined with task-related training improves lower limb functions in subjects with chronic stroke. Stroke 2007; 38(11): 29532959Google ScholarCrossrefMedline
12. Hiraoka, K. Neural mechanisms underlying the effect of transcutaneous electrical nerve stimulation in humans. Electromyogr Clin Neurophysiol 2002; 42(6): 359366Google ScholarMedline
13. Veerbeek, JM, van Wegen, E, van Peppen, R. What is the evidence for physical therapy poststroke? A systematic review and meta-analysis. PLoS ONE 2014; 9(2): e87987Google ScholarCrossrefMedline
14. Mills, PB, Dossa, F. Transcutaneous electrical nerve stimulation for management of limb spasticity: a systematic review. Am J Phys Med Rehabil 2016; 95(4): 309318Google ScholarCrossrefMedline
15. Ng, SS, Lai, CW, Tang, MW. Cutaneous electrical stimulation to improve balance performance in patients with sub-acute stroke: a randomised controlled trial. Hong Kong Med J 2016; 22(Suppl 2): S33S36Google ScholarMedline
16. Jung, KS, In, TS, Cho, HY. Effects of sit-to-stand training combined with transcutaneous electrical stimulation on spasticity, muscle strength and balance ability in patients with stroke: A randomized controlled study. Gait Posture 2017; 54: 183187Google ScholarCrossrefMedline
17. Park, J, Seo, D, Choi, W. The effects of exercise with TENS on spasticity, balance, and gait in patients with chronic stroke: a randomized controlled trial. Med Sci Monit 2014; 20: 18901896Google ScholarCrossrefMedline
18. Kumar, C, Kulkarni, CM. Comparison between electrical stimulation over motor point and TENS over acupuncture point in reducing spasticity and improving function after stroke: randomized clinical trial. Int J Phys Med Rehabil 2014; 2(6): 237Google Scholar
19. Moseley, AM, Herbert, RD, Sherrington, C. Evidence for physiotherapy practice: a survey of the Physiotherapy Evidence Database (PEDro). Aust J Physiother 2002; 48(1): 4349Google ScholarCrossrefMedline
20. Ng, SS, Hui-Chan, CW. The timed up & go test: its reliability and association with lower-limb impairments and locomotor capacities in people with chronic stroke. Arch Phys Med Rehabil 2005; 86(8): 16411647Google ScholarCrossrefMedline
21. Feiveson, AH. What is the delta method and how is it used to estimate the standard error of a transformed parameter? 2005http://www.stata.com/support/faqs/statistics/delta-method/ Google Scholar
22. Hedges, LV, Olkin, I. Statistical methods for meta-analysis. Orland, FLAcademic Press2014Google Scholar
23. Higgins, JPT, Green, S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration2011http://handbook.cochrane.orgGoogle Scholar
24. Egger, M, Davey Smith, G, Schneider, M. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315(7109): 629634Google ScholarCrossrefMedline
25. Foley, NC, Teasell, RW, Bhogal, SK. Stroke rehabilitation evidence-based review: methodology. Top Stroke Rehabil 2003; 10(1): 17Google ScholarCrossref
26. Thompson, SG, Higgins, J. How should meta-regression analyses be undertaken and interpreted? Stat Med 2002; 21(11): 15591573Google ScholarCrossrefMedline
27. Yavuzer, G, Oken, O, Atay, MB. Effect of sensory-amplitude electric stimulation on motor recovery and gait kinematics after stroke: a randomized controlled study. Arch Phys Med Rehabil 2007; 88(6): 710714Google ScholarCrossrefMedline
28. Deshmukh, MK, Kumar, C, Goyal, M. Application of transcutaneous electrical stimulation on lower limb acupoints as an important adjunctive tool in stroke rehabilitation program & its effects on spasticity and functional ability. Int J Physioth Res 2013; 3: 6367Google Scholar
29. Tekeolu, Yb, Adak, B, Göksoy, T. Effect of transcutaneous electrical nerve stimulation (TENS) on Barthel Activities of Daily Living (ADL) index score following stroke. Clin Rehabil 1998; 12(4): 277280Google ScholarLink
30. Hui-Chan, CW, Ng, SS, Mak, MK. Effectiveness of a home-based rehabilitation programme on lower limb functions after stroke. Hong Kong Med J 2009; 15(3, Suppl 4): 4246Google ScholarMedline
31. Sonde, L, Kalimo, H, Fernaeus, SE. Low TENS treatment on post-stroke paretic arm: a three-year follow-up. Clin Rehabil 2000; 14(1): 1419Google ScholarLink
32. Sonde, L, Gip, C, Fernaeus, SE. Stimulation with low frequency (1.7 Hz) transcutaneous electric nerve stimulation (low-TENS) increases motor function of the post-stroke paretic arm. Scand J Rehabil Med 1998; 30(2): 9599Google ScholarCrossrefMedline
33. Bakheit, AMO, Maynard, VA, Curnow, J. The relation between Ashworth scale scores and the excitability of the alpha motor neurones in patients with post-stroke muscle spasticity. J Neurol Neurosur Ps 2003; 74(5): 646648Google ScholarCrossrefMedline
34. Patrick, E, Ada, L. The Tardieu Scale differentiates contracture from spasticity whereas the Ashworth Scale is confounded by it. Clin Rehabil 2006; 20(2): 173182Google ScholarLink
35. Ng, SS, Hui-Chan, CW. Ankle dorsiflexion, not plantarflexion strength, predicts the functional mobility of people with spastic Hemiplegia. J Rehabil Med 2013; 45(6): 541545Google ScholarCrossrefMedline
36. Lomaglio, MJ, Eng, JJ. Muscle strength and weight-bearing symmetry relate to sit-to-stand performance in individuals with stroke. Gait Posture 2005; 22(2): 126131Google ScholarCrossrefMedline
37. Koyama, S, Tanabe, S, Takeda, K. Modulation of spinal inhibitory reflexes depends on the frequency of transcutaneous electrical nerve stimulation in spastic stroke survivors. Somatosens Mot Res 2016; 33(1): 815Google ScholarCrossrefMedline
38. Laddha, D, Ganesh, GS, Pattnaik, M. Effect of transcutaneous electrical nerve stimulation on plantar flexor muscle spasticity and walking speed in stroke patients. Physiother Res Int 2016; 21(4): 247256Google ScholarCrossrefMedline
39. Duncan, PW, Goldstein, LB, Horner, RD. Similar motor recovery of upper and lower extremities after stroke. Stroke 1994; 25(6): 11811188Google ScholarCrossrefMedline
40. Kaneko, T, Caria, MA, Asanuma, H. Information processing within the motor cortex. II. Intracortical connections between neurons receiving somatosensory cortical input and motor output neurons of the cortex. J Comp Neurol 1994; 345(2): 172184Google ScholarCrossrefMedline
41. Lai, MI, Pan, LL, Tsai, MW. Investigating the effects of peripheral electrical stimulation on corticomuscular functional connectivity stroke survivors. Top Stroke Rehabil 2016; 23(3): 154162Google ScholarCrossrefMedline
42. Veldman, MP, Zijdewind, I, Solnik, S. Direct and crossed effects of somatosensory electrical stimulation on motor learning and neuronal plasticity in humans. Eur J Appl Physiol 2015; 115(12): 25052519Google ScholarCrossrefMedline

via Transcutaneous electrical nerve stimulation improves walking capacity and reduces spasticity in stroke survivors: a systematic review and meta-analysisClinical Rehabilitation – Patrick WH Kwong, Gabriel YF Ng, Raymond CK Chung, Shamay SM Ng, 2017

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