Project details
Total cost: EUR 8 186 684,46
EU contribution: EUR 6 000 000
Coordinated in: Italy
Call for proposal:
FP7-HEALTH-2013-INNOVATION-1See other projects for this call
Funding scheme:
CP-FP – Small or medium-scale focused research project
Objective
Neurostemcellrepair aims at taking human stem cells through the final steps toward clinical application in cell replacement therapy for neurological disorders. PD will be taken as the prototypical disease because stem cell therapy is now close to clinical translation. Moreover, we will tackle next generation issues pertaining to stem cells at a basic level and develop new approaches and novel cell sources, validated at pre-clinical stages, for both PD and HD. The project teams represent a wide range of competences, including stem cell specialists, developmental neurobiologists, experts in neurodegeneration, scientists with links to the clinic and stem cell manufacturing/clinical validation. The research plan is constructed on exchange of tools, sharing of protocols and expertise and joint deliverables among the participants. We will address issues related to the control of progenitor proliferation and differentiation into authentic, functional and phenotypically stable dopaminergic or striatal neurons, and exploit new technology for cell reprogramming. We will develop strategies to obtain endurable donor cell engraftment in the host, including acquisition of specific neuronal identities and functional integration in the recipient brain. The therapeutic effect will be evaluated following transplantation in animal models of PD and HD. Cutting edge technologies will be guaranteed by the involvement of three SMEs, one industry and partners experienced in bioengineering, who will collectively provide a toolbox to deliver ontogenetic and reprogramming factors, small molecules and miRNA, immunoseparation strategies, in vivo monitoring of donor cell behaviour, scale up and GMP-compliant protocols. Ultimately, Neurostemcellrepair is expected to develop new cell sources based on cellular reprogramming, make significant advance towards stem cell therapy in HD, and close the gap between development and clinical implementation of stem cell replacement therapies for PD.
Related information
Result In Brief Stem cell therapy for neurological disorders
Report Summaries
- Periodic Report Summary 1 – NEUROSTEMCELLREPAIR (European stem cell consortium for neural cell replacement, reprogramming and functional brain repair)
- Periodic Report Summary 2 – NEUROSTEMCELLREPAIR (European stem cell consortium for neural cell replacement, reprogramming and functional brain repair)
Open Access publications
(21)via 
- Reciprocal Regulation between Bifunctional miR-9/9? and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation
- Biobanking shifts to “precision medicine”
- REST suppression mediates neural conversion of adult human fibroblasts via microRNA?dependent and ?independent pathways
- Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?
- Whole-brain 3D mapping of human neural transplant innervation
- G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson?s disease
- Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons
- hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation
- Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson?s Disease
- In?Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry
- Small molecules increase direct neural conversion of human fibroblasts
- Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy
- Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor
- Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons
- Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain
- Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson’s disease
- Modeling psychiatric disorders: from genomic findings to cellular phenotypes
- Synaptic dysfunction in early encephalopathies : from genes to function
- The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification
- Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease
- Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders
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