[ARTICLE] A protocol of systematic review and meta-analysis of acupuncture for drug resistant epilepsy – Full Text



This study aims to appraise the effectiveness and safety of acupuncture for drug resistant epilepsy (DRE).


We will search all potential randomized controlled trials (RCTs) of acupuncture for patients with DRE from their origin to March 1, 2020: MEDLINE, EMBASE, Cochrane Library, CINAHL, Scopus, WANGFANG, and Chinese Biomedical Literature Database. We will not apply any restrictions to the language and publication date. All RCTs investigating the effectiveness and safety of acupuncture for patients with DRE will be included. Study quality will be appraised by Cochrane risk of bias, and statistical analysis will be scrutinized by RevMan 5.3 software. Whenever possible, a narrative summary to describe study quality and content of the evidence will be performed.


This study will provide summarize high quality evidence and will utilize a variety of outcome measurements to verify effectiveness and safety of acupuncture for DRE.


The results of this study will seek to explore the effectiveness and safety of acupuncture for DRE.

1 Introduction

Epilepsy is a chronic neurological disease that is caused by a variety of factors.[1,2] It is characterized by recurrent, episodic and temporary neurological function impairments because of the excessive discharge of brain neurons.[3] Epidemiological studies reported the prevalence rate of epilepsy is about 1%.[4] Despite numerous antiepileptic drugs are available for the management of epilepsy, there are more than 30% patients progressing to drug-resistant epilepsy (DRE),[5] which causes increasing morbidity and mortality.[6–8]

Acupuncture has been utilized in treating a variety of disorders, such as pain, allergic rhinitis, post-stroke spastic hemiplegia, fertilization, cardiac arrhythmia, migraine, perimenopausal depressive disorder, overactive bladder, uterine fibroids, urinary incontinence, hiccups, and epilepsy.[9–31] Although published systematic reviews assessed the effectiveness and safety of acupuncture for the treatment of patients with epilepsy,[27,30] no study has specifically addressed its efficacy and safety for the treatment of patients with DRE. In addition, an increasing number of clinical trials focus on acupuncture in treating DRE.[32–46] Thus, this systematic review will specifically investigate the effectiveness and safety of acupuncture in treating DRE.



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