Posts Tagged amphetamines

[Abstract] Cannabis and other illicit drug use in epilepsy patients – Hamerle – 2013 – European Journal of Neurology.

Abstract

Background and purpose

This study aimed to assess the prevalence of illicit drug use among epilepsy patients and its effects on the disease.

Methods

We systematically interviewed epilepsy outpatients at a tertiary epilepsy clinic. Predictors for active cannabis use were analysed with a logistic regression model.

Results

Overall, 310 subjects were enrolled; 63 (20.3%) reported consuming cannabis after epilepsy was diagnosed, and 16 (5.2%) used other illicit drugs. Active cannabis use was predicted by sex (male) [odds ratio (OR) 5.342, 95% confidence interval (95% CI) 1.416–20.153] and age (OR 0.956, 95% CI 0.919–0.994). Cannabis consumption mostly did not affect epilepsy (84.1%). Seizure worsening was observed with frequent illicit (non-cannabis) drug use in 80% of cases.

Conclusions

Cannabis use does not seem to affect epilepsy; however, frequent use of other drugs increases seizure risk.

Source: Cannabis and other illicit drug use in epilepsy patients – Hamerle – 2013 – European Journal of Neurology – Wiley Online Library

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[REVIEW] Miscellaneous Treatments | EBRSR – Evidence-Based Review of Stroke Rehabilitation – Full Text PDF

Abstract

The medical management of stroke is often a dynamic process. While treatment regimens have been established, practitioners and patients are constantly searching for new techniques to improve patient outcomes. The use of treatments not traditionally taught in medical schools has begun to gain popularity. Reports suggest that up to 40% of adults living in the United States and elsewhere have used some form of Complimentary and Alternative Medicine to treat a health problem (Astin et al. 2000). Physicians and researchers are also using standard interventions in new ways to treat difficult medical complications. New applications for medications and technologies are regularly being evaluated. In this review, we examine the use of miscellaneous treatments as they relate to patients who have suffered a stroke. Evidence regarding complimentary and alternative medicine, medications used for the treatment of motor and language recovery, and new technological therapies are evaluated. Alternative therapies include acupuncture, traditional Chinese patent medicine, Reiki, and massage therapy. Medications include those specifically used to aid in motor and language recovery. New technological therapies assessed are hyperbaric oxygen therapy, repetitive transcranial magnetic stimulation, and motor cortex stimulation.

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via Miscellaneous Treatments | EBRSR – Evidence-Based Review of Stroke Rehabilitation.

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[ARTICLE] A Combined Therapeutic Approach in Stroke Rehabilitation: A Review on Non-Invasive Brain Stimulation plus Pharmacotherapy -Full Text PDF

Abstract

Stroke is a leading cause of disability in the United States. Available treatments for stroke have only a modest effect on motor rehabilitation and about 50-60% of stroke patients remain with some degree of motor impairment after standard treatment.

Non-invasive brain stimulation (NIBS) techniques have been proposed as adjuvant treatments to physical therapy for motor recovery after stroke. High frequency rTMS and anodal tDCS can be delivered over the affected motor cortex in order to increase cortical excitability and induce brain plasticity with the intention to enhance motor learning and achieve functional goals in stroke patients. Similarly, low frequency rTMS and cathodal tDCS can be delivered to the unaffected motor cortex to reduce interhemispheric inhibition and hinder maladaptive plasticity.

The use of several drugs such as amphetamines, selective serotonin reuptake inhibitors (SSRIs), levodopa and cholinergic agents have been also proposed to enhance the motor function. Given that both NIBS and pharmacotherapy might provide some treatment effect independently for motor rehabilitation in stroke and with the rationale that they could work in a synergistic fashion, we believe that a combined therapy- NIBS plus pharmacotherapy- can lead to better outcomes than one or the other alone. In this paper we review the literature that support the potential use of a combined approach in stroke recovery and present the studies that have already investigated this idea

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