[Abstract] Impaired visual competition in patients with homonymous visual field defects.

Highlights

Humphrey perimetry shows partial field recovery in patients with homonymous visual field defects after post-chiasmatic lesions.Visual decision-making is deviating from healthy controls, even in the ipsilateral, assumed ’intact’ visual field.Patients, however, do show a slight hint of primacy as healthy controls, but these effects are disrupted by their tendency to guess.Rehabilitation methods may profit from training focused on improving visual decision-making of the defective and the intact visual field.

Abstract

Intense visual training can lead to partial recovery of visual field defects caused by lesions of the primary visual cortex. However, the standard visual detection and discrimination tasks, used to assess this recovery process tend to ignore the complexity of the natural visual environment, where multiple stimuli continuously interact. Visual competition is an essential component for natural search tasks and detecting unexpected events.

Our study focused on visual decision-making and to what extent the recovered visual field can compete for attention with the ’intact’ visual field. Nine patients with visual field defects who had previously received visual discrimination training, were compared to healthy age-matched controls using a saccade target-selection paradigm, in which participants actively make a saccade towards the brighter of two flashed targets. To further investigate the nature of competition (feed-forward or feedback inhibition), we presented two flashes that reversed their intensity difference during the flash. Both competition between recovered visual field and intact visual field, as well as competition within the intact visual field, were assessed.

Healthy controls showed the expected primacy effect; they preferred the initially brighter target. Surprisingly, choice behaviour, even in the patients’ supposedly ‘intact’ visual field, was significantly different from the control group for all but one. In the latter patient, competition was comparable to the controls. All other patients showed a significantly reduced preference to the brighter target, but still showed a small hint of primacy in the reversal conditions.

The present results indicate that patients and controls have similar decision-making mechanisms but patients’ choices are affected by a strong tendency to guess, even in the intact visual field. This tendency likely reveals slower integration of information, paired with a lower threshold. Current rehabilitation should therefore also include training focused on improving visual decision-making of the defective and the intact visual field.

Source: Impaired visual competition in patients with homonymous visual field defects.

[Abstract] Homonymous Hemianopia and Vision Restoration Therapy

Homonymous hemianopia from stroke causes visual disability. Although some patients experience spontaneous improvement, others have limited to no change and may be left with a severe disability. Current rehabilitation strategies are compensatory and cannot restore function. Animal studies suggest that central nervous system plasticity could allow for redirection of lost visual function into undamaged areas of cortex. A commercial therapy system was developed, from which claims of visual field expansion were disputed by independent researchers. The treatment remains controversial with seemingly contradictory data being generated. Continued research is underway to demonstrate the (non-)efficacy of this treatment method.

Source: Homonymous Hemianopia and Vision Restoration Therapy – Neurologic Clinics

[ARTICLE] Enhancing Visual Performance in Individuals with Cortical Visual Impairment (Homonymous Hemianopsia): Tapping into Blindsight – Full Text PDF

Visual improvement of a subject with left homonymous hemianopsia visual field defect from right occipital traumatic brain injury: A) Before treatment; B) After treatment using augmented reality goggles.

Highlights

Patients with occipital lobe damage may have blind areas in their visual field.

Other non-cortical areas of the brain still process visual information.

Modifying visual input can stimulate non-cortical visual processing areas.

Augmented virtual reality goggles as a therapy for cortical blindness is proposed.

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Abstract

Homonymous hemianopsia is a type of cortical blindness in which vision is lost completely or partially in the left half or the right half of the field of vision. It is prevalent in approximately 12% of traumatic brain injury and 35% of strokes. Patients often experience difficulty with activities such as ambulating, eating, reading, and driving. Due to the high prevalence of homonymous hemianopsia and its associated difficulties, it is imperative to find methods for visual rehabilitation in this condition. Traditional methods such as prism glasses can cause visual confusion and result in patient noncompliance. There is a large unmet medical need for improving this condition. In this article, we propose that modifying visual stimuli to activate non-cortical areas of visual processing, such as lateral geniculate nucleus and superior colliculus, may result in increased visual awareness. Presenting high contrast and low spatial frequency visual stimuli can increase visual detection in patients with cortical blindness, a phenomenon known as blindsight. Augmented virtual reality goggles have the potential to alter real-time visual input to high contrast and low spatial frequency images, possibly improving visual detection in the blind hemifield and providing an alternative therapy for homonymous hemianopsia.

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Introduction

Cortical visual impairment comprises a significant component of strokes and traumatic brain injury. Cortical visual impairment includes homonymous hemianopsia, in which vision is lost completely or partially in the left half or the right half of the field of vision. Homonymous hemianopsia is prevalent in approximately 12% of traumatic brain injury and 35% of strokes [1], [2] and [3]. Individuals with this vision loss usually have difficulties with activities of daily living such as ambulating, eating, reading, and driving [4] and [5]. Due to the high prevalence of homonymous hemianopsia and its associated difficulties, it is imperative to find methods for visual rehabilitation in this condition. Traditional methods of visual rehabilitation for homonymous hemianopsia include fitting spectacles with prisms to shift the visual field from the blind hemifield to the intact visual field. This is accomplished by placing the base of the prism in the blind hemifield, which shifts the image toward the apex of the prism into the intact hemifield. Many patients discontinue treatment with prisms because the prisms may induce visual confusion and double vision[1], [2], [3] and [4]. Another technique used is to train individuals with hemianopsia to make quick eye movements in the direction of the blind hemifield, though there is not much evidence supporting efficacy [6]. Although these methods may provide some compensation for the visual field loss, they do not restore the impaired visual field. Accordingly, other methods of improving vision are needed.

Individuals with homonymous hemianopsia do not consciously see vision in the blind hemifield. However, there is evidence of a ‘blindsight’ phenomenon, whereby some affected individuals can detect objects in their blind visual field, albeit without conscious awareness of being able to see the object. Functional magnetic resonance imaging (fMRI) studies have indicated that visual processing occurs in other parts of the brain, such as the lateral geniculate nucleus (LGN) and superior colliculus (SC) (Fig. 1). Visual processing in these regions provides the neural network that enables patients with blindsight to see [7], [8], [9], [10] and [11]. Blindsight has been manipulated in some individuals to enhance visual awareness. Weiskrantz et. al studied a patient with homonymous hemianopsia and well-documented blindsight over a long period of time [7]. The patient reported increased awareness of visual stimuli in his blind visual field when the stimulus was presented with high contrast and low spatial frequency. Spatial frequency refers to the level of detail in an image appearing within a degree of the visual field. Temporal frequency, the number of times a stimulus is flashed within a second, also modulates detection. Multiple studies have shown that within a temporal frequency range of 5-20 Hz (cycles/second), detection of visual stimuli in a forced-choice test is significantly better than chance [7], [8], [9], [10] and [11]. The time of stimulus onset also affects the rate of detection. Patients with parietal lobe injury often cannot detect a visual stimulus in the neglected hemifield when it is presented simultaneously in the intact hemifield, but can detect the stimulus when it is presented by itself in the neglected hemifield only, a phenomenon known as visual extinction [12] and [13]. It is thought that visual extinction reflects an attentional deficit as opposed to primarily a sensory deficit, although this remains an area of active research [14]. Despite that visual extinction is primarily studied in patients with hemi-neglect, patients with hemianopsia also can have hemi-neglect from injury to both the occipital and parietal lobes [15]. Therefore, the relevant visual variables for increasing visual detection in hemianopsia are stimuli contrast, spatial frequency, temporal frequency and stimulus onset asynchrony.

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