Posts Tagged neurological disorders

[WEB SITE] Is Stem Cell Therapy Effective?

Is stem cell therapy safe and effective?

Find out if the therapy is beneficial for a specific disease,
how and why it works and what the treatment involves

This article is written by Eremin Ilya – Vice Director for Science and Research at Swiss Medica clinic.

Swiss Medica specializes in the most cutting edge stem cell therapies for 8 years. Their head office is based in Switzerland and they have treatment centers in Russia, Moscow and Serbia, Belgrade.
As a result, patients have seen a halt in the progression and/or symptoms of a vast array of diseases, such as arthritis, diabetes, multiple sclerosis, autism, Parkinson’s and other hard to treat diseases.

What are stem cells?
Stem cells are the unique types of cells that are able to replicate itself and to launch the regeneration processes. Stem cells are circulating into the body and looking for damaged areas to repair them. They are also able to put out the inflammation.

This helps to eliminate the cause of the disorders, to reduce its symptoms or even to get a full recovery, depends on the initial condition. And the most important, stem cell treatment is a gentle way of healing that is safe and side-effect free in most cases.

When you undergo cell-based treatment, you get 100+ million viable stem cells in one dose. Cells are harvested from the patient’s body and then cultivated to this quantity. Donated stem cells can be also used for immediate treatment.

Not for all cases, but there is a high percentage of getting health improvements that can be reached in variety diseases.

 

What are the expected results?
Using stem cells in therapy helps to reduce symptoms and can even stop or reverse the progression of some diseases, mostly autoimmune and/or diseases associated with tissue damage. These types of cells trigger the healing process and help to:

– relieve inflammation;
– reduce pain;
– repair wounds and damaged tissues;
– stimulate the formation of neurons and new blood vessels;
– restore lost functions;
– eliminate the signs of aging.

Depending on the patient’s condition, we use cell products based on autologous (patient’s own) or donor cells. Activated stem cells can be administered in several ways, depending on the purpose of the therapy, the disease, and the patient’s condition (IV, intrathecal, intramuscular, retrobulbar or local injection).

 

It is important to understand that stem cells are not a guaranteed cure for every disease.The patient may be denied stem cell procedures for various reasons. The effectiveness of the therapy for a particular disease depends on multiple factors: duration of the illness, age of the patient, the existence of chronic conditions, hereditary predisposition, lifestyle, etc.

Applying only stem cells for some cases may be not enough. Cell therapy works more effectively when combined with other therapeutic methods that help decrease inflammation, restore mobility, activate the tissue repair process

 

How do stem cells work?
The main therapeutic effect of stem cells is their ability to produce cytokines and growth factors in the intercellular space. These special chemicals are able to activate the regenerative functions of distant cells and promote tissue recovery. This mechanism is called paracrine regulation.

Cytokines help block the signals of inflammation in various diseases, including autoimmune processes [1]. An important feature of these signal molecules is that their concentrations may be regulated by inflammation and may be strictly limited by the stage of tissue regeneration. We can boost the production of cytokines using cell products based on stromal cells, leading to improved function of the damaged tissue.

When stem cells are introduced into a patient’s body during therapy, they circulate in the blood system until they are attracted to proteins secreted around inflamed or damaged tissue. Stem cells then rush to that injured area and start producing:
– various growth factors (promoting tissue recovery);
– chemokines (helping cells to migrate);
– adhesion molecules (regulating cell interactions at the molecular level).

How the procedure is carried out?
First, the patient undergoes a full examination to determine the current state of health. Then specialist makes a conclusion about the appropriateness and expected effects of therapy.
Next, the question is whether self-sourced or donor stem cells will be used. In the first case, the biopsy is performed and stromal cells are isolated from the patient’s own biomaterial. Then the harvested cells are cultivated to the required volume. Usually, this takes 3-4 weeks depending on the proliferative potential of the MMSCs. After that, the cultivated cells can be used for therapy or stored in a cryobank for an unlimited period of time. In the case of donor cells, the cell product can be used immediately in the initial treatment.

The use of cell products is carried out under medical supervision. The volume of cell mass required for treatment is calculated depending on the patient’s body weight. Before use, a test for sterility and infectious/bacteriological safety is carried out. Then a passport of the cell product is drawn up. This passport indicates the name of the cell product, the source of cells, date of extraction, cells characteristics, description of final product formulation, etc.

When the cell product is ready for use, it can be administered in several ways, depending on the purpose of therapy, the disease, and the patient’s condition:

  • IV drip;
  • Intramuscularly;
  • Intrathecal (spinal tap);
  • Retrobulbar (in the eye area);
  • Locally (cutaneous covering, joint, cavernous bodies of the penis, etc.).

What are the indications, contraindications and side effects?

Treatment with cell products is usually appealed in cases where the standard therapy of the underlying disease is not adequately effective or is associated with complications.

Before therapy, it is necessary to exclude contraindications for cell treatment, including:
– Previous bad experience with cell products;
– Any acute infectious disease;
– Cancer or a precancerous condition;
– Stroke or transient ischemic attack in the last 3 months;
– Deviations of some indicators in blood tests;
– Mental disorders and addictions;
– Contraindications to anesthesia and/or high risk of bleeding and/or pathological processes in the area of the proposed biopsy (does not exclude the possibility of using donor cell products);
– Pregnancy and lactation, and some others.

Along with the expected improvements in cell therapy, unwanted side effects are rare and include allergic and pyrogenic posttransfusion reactions (short-term fever), which are both easily managed.

In a majority of cases, it is possible to decline the manifestations of the disease, weaken pain symptoms, and correct the function that was affected. The therapies generally improve the standard of living.

Safety of stem cell therapy
The procedures are usually well tolerated in the majority of patients. Clinical trial results confirmed the safety of local injections and treatment with MMSCs from the perspective of tumor formation after a follow-up period [6]. Individual intolerance (short-term fever), while rare, cannot be excluded. Swiss Medica specialists will monitor your condition for safer and more beneficial results. [2], [3].
When it comes to improvement?
It usually takes a few weeks or months until transplanted cells start to fully take effect, although the first improvements can be felt in the days after administration. Often, reduced pain, enhanced mobility of affected joints, improved energy and activity, improved indicators of diagnostic tests can be realized relatively quickly.

Transplanted stem cells are active for 3 months on average, 6 months as a maximum. After this period, the stem cells are no longer active, but the processes started by them continue. A complex effect is possible where not only the manifestations of the underlying disease are reduced, but also the general condition of the patient is improved.

Your doctor may recommend you to seek a second consultation after 3 and/or 6 months after cell introduction in order to assess the effectiveness of the therapy. To achieve a greater and more persistent effect, the therapy can be repeated after a recommended period of time. […]

 

For more visit site —->  Swiss Medica Article – Is Stem Cell Therapy Effective?

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[WEB SITE] Virtual Reality: New Therapy for Neurological Disorders

Virtual Reality: New Therapy for Neurological Disorders

Emerging technology in the form of virtual reality (VR) may provide a new tool to aid treatment for neurological disorders such as autism, schizophrenia and Parkinson’s disease. A recent study suggests that playing games in VR could help individuals with these neurological conditions shift their perceptions of time, which their conditions lead them to perceive differently.

Researchers from the University of Waterloo discovered VR can help improve an individual’s perception of time. “The ability to estimate the passage of time with precision is fundamental to our ability to interact with the world,” says co-author Séamas Weech, a post-doctoral fellow in Kinesiology.

“For some individuals, however, the internal clock is maladjusted, causing timing deficiencies that affect perception and action. Studies like ours help us to understand how these deficiencies might be acquired, and how to recalibrate time perception in the brain.”

Researchers tested 18 females and 13 males with normal vision and no sensory, musculoskeletal or neurological disorders. The researchers used a virtual reality game, Robo Recall, to create a natural setting in which to encourage re-calibration of time perception.

The key manipulation of the study was that the researchers coupled the speed and duration of visual events to the participant’s body movements.

The researchers measured participants’ time perception abilities before and after they were exposed to the dynamic VR task. Some participants also completed non-VR time-perception tasks, such as throwing a ball, to use as a control comparison.

Investigators measured the actual and perceived durations of a moving probe in the time perception tasks. They discovered that the virtual reality manipulation was associated with significant reductions in the participants’ estimates of time, by around 15 percent.

“This study adds valuable proof that the perception of time is flexible, and that VR offers a potentially valuable tool for recalibrating time in the brain,” says Weech. “It offers a compelling application for rehabilitation initiatives that focus on how time perception breaks down in certain populations.”

Weech adds, however, that while the effects were strong during the current study, more research is needed to find out how long the effects last, and whether these signals are observable in the brain.

“For developing clinical applications, we need to know whether these effects are stable for minutes, days, or weeks afterward. A longitudinal study would provide the answer to this question.”

“Virtual reality technology has matured dramatically,” says Michael Barnett-Cowan, neuroscience professor and senior author of the paper.

“VR now convincingly changes our experience of space and time, enabling basic research in perception to inform our understanding of how the brains of normal, injured, aged and diseased populations work and how they can be treated to perform optimally.”

Source: University of Waterloo

 

via Virtual Reality: New Therapy for Neurological Disorders

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[WEB SITE] Functional Strokes – Rehabilitation: Can hypnotic (and allied) techniques help?

Professor Jon Stone started the day by talking about the diagnostic techniques, aetiology and treatment of Functional Motor Disorders. Rather than being a diagnosis formed by exclusion, Professor Stone showed that there are positive diagnostic signs of a functional disorder. Rather than being ‘all in the mind’, they are a disorder of function that may have a variety of psychogenic underpinnings and sometimes no obvious emotional or traumatic trigger. Functional Disorders are something that all humans experience to a greater or lesser extent, from such things as a tension headache to irritable bowel syndrome or functional stroke. Functional Neurological Disorders ‘are no longer assumed to be only the result of ‘conversion’ of psychological conflict but now understood as a complex interplay between physiological stimulus, expectation, learning and attention…. with biopsychosocial predisposing, triggering and perpetuating inputs’.1

Dr Ranjan Sanyal, a Consultant Stroke Physician, University Hospitals of North Midlands then described how he uses hypnosis with functional strokes. Functional disorders are very common and are responsible not only for a large amount of human suffering, but also a huge cost to the economy of over £14 billion.2 8.4% of all strokes are functional and the condition can be as debilitating as Parkinson’s or Multiple Sclerosis. Dr Sanyal described how he uses hypnosis very successfully with his patients, building rapport, using imagery, and giving appropriate suggestions in hypnosis. Dr Alastair Dobbin then talked about how positive and negative episodic memories that lie outside of conscious awareness can influence our feelings of autonomy, competence and relatedness. Someone with resilience has rapid access to positive emotions which speeds recovery from a threat, so our therapies should seed or prime a growth or recovery model in our patients.

Pauline Halliday, an Occupational Therapist and a Clinical Specialist in stroke, then gave a presentation as to how she used hypnosis to help a ‘difficult’ stroke patient with ‘functional overlay’. By means of a simple breathing induction and using imagery of a safe, calm place and a beach, that the patient could go to in her imagination, her agitation and anxiety were reduced. She was taught how to use this whenever she wanted to feel calmer. This also improved her sleep pattern. Pauline also uses hypnosis with patients with Thalamic or Central Pain Syndrome using the patient’s metaphors in hypnosis to help a change in perception (switches, water, warmth etc.) with a resultant reduction in analgesic medication. She has also used hypnosis successfully to manage fear of going into the MRI Scanner, during Carotid Endarterectomy, with Functional Stroke (mainly with vocal dysfunction), and generalised anxiety.

After lunch, Dr Jason Price, a prominent Consultant Neuropsychologist from South Tees Hospital NHS Trust talked about how the profile of hypnosis in the NHS suffers from ‘alternative therapy’ perception. Far from being an ‘alternative therapy’ Dr Price argues, hypnosis sits comfortably within the ‘3rd Wave’ cognitive therapies such as Mindfulness, Acceptance and Commitment Therapy, Compassion Focused Therapy, DBT and Transdiagnostic Therapy. There is also good evidence of ‘added value’ of hypnosis with other ‘mainstream’ therapies. He pointed out the importance of imagery, not only in hypnosis but also within these other therapeutic approaches. It works in a primary modality and is very powerful in re-scripting/ cognitive restructuring in trauma work.3Visual Imagery is recommended for post-stroke limb movement recovery (National Clinical Guideline for Stroke 5th edition, 2016) and there are similarities, as well as some differences between hypnosis and mindfulness4,5 and hypnosis and EMDR.6 Hypnosis can both reproduce and remove functional symptoms, ‘turn off’ the neural circuits involved in agency, the executive processes involved in self-monitoring and automatic neuropsychological processes.7 With EEG and fMRI evidence the development of cognitive neuroscientific understanding of hypnosis has developed alongside contemporary cognitive neuroscience understanding of Functional Neurological Disorders.8-11

Dr Paul Molyneux, a Consultant Neurologist from West Suffolk Hospital Trust and Addenbrookes, then reported how he uses hypnosis within an out-patient department treating Non-Epileptic Seizures and migraine. In a busy clinic there is very little time to make a diagnosis let alone treat the condition but informal hypnotic techniques can help. This involves using reflective listening, with attention to body language, confirming and explaining the diagnosis while building rapport, together with the careful use of language and metaphor, especially when breaking the diagnosis of Non-Epileptic Seizures.12 He stressed the importance of touch and giving reassurance by physical examination and then using a simple hypnotic induction to increase the effectiveness of the positive suggestions given. Dr Molyneux also described how he uses hypnosis and metaphorical imagery to help patients with migraines. Self-hypnosis gives the patient a life long tool.

This was followed by Devin Terhune from Goldsmith’s University of London describing his recent meta-analysis of hypnotic suggestibility in functional and dissociative disorders which support an increased hypnotic susceptibility. The limitations of methodology give rise to a weak scientific evidence base despite the fact that patients and doctors find hypnosis helpful and empowering.

The final presentation of the day was given by Professor Charles Warlow, Emeritus Professor of Medical Neurology at Western General Hospital, summarising why hypnosis has been underutilised in the past and how it could be used in the future.

A most fascinating day was ended by a general panel discussion between the presenters and the audience on the way forward for hypnosis in the management of Functional Neurological Disorders.

References

  1. Complex regional pain syndrome and functional neurological disorders: time for reconciliation. Popkirov S, Hoeritzauer I, Colvin L, Carson A & Stone J (2018) Journal of Neurology, Neurosurgery & Psychiatry. Published Online First: 24 October 2018. doi: 10.1136/jnnp-2018-318298
  2. The cost of somatisation among the working‐age population in England for the year 2008–2009. (2010) Bermingham S, Cohen A, Hague J & Parsonage M. Mental Health in Family Medicine. Vol 7(2): 71–84.
  3. Imagery re-scripting and reprocessing therapy after failed prolonged exposure for post-traumatic stress disorder following industrial injury. (2007) Grunert B K, Weis J M, Smucker M R, Christianson H F. Journal of Behaviour Therapy & Experimental Psychiatry. Vol 38 (4) 317-28.
  4. Do Hypnosis and Mindfulness Practices Inhabit a Common Domain? Implications for Research, Clinical Practice, and Forensic Science. (2012) Lynn S, Malaktaris A, Maxwell R, Mellinger D & van der Kloet D. Journal of Mind-Body Regulation. Vol 2 (1) 12-26
  5. Metacognition of intentions in mindfulness and hypnosis. (2016) Lush P, Naish P & Dienes Z. Neuroscience of Consciousness. Volume 2016, Issue 1, 1 January 2016
  6. Introduction to the Special Section: Hypnosis and EMDR. (2001) Frischholz J, Kowal J & Hammond, D. The American Journal of Clinical Hypnosis. Vol 43(3-4) 179-182
  7. Hypnosis as therapy for functional neurologic disorders. (2017) Deeley Q. Handbook of Clinical Neurology. Vol 139, 585-595
  8. Brain Activity and Functional Connectivity Associated with Hypnosis. (2017) Jiang H, White M, Greicius M, Waelde L & Spiegel D. Cerebral Cortex. Vol 27 (8) 4083-4093.
  9. Neuro-hypnotism: prospects for hypnosis and neuroscience. (2013) Kihlstrom J. Cortex. Vol 49 (2) 365-74.
  10. Hypnotic induction is followed by state-like changes in the organization of EEG functional connectivity in the theta and beta frequency bands in high-hypnotically susceptible individuals. (2014) Jamieson G & Burgess A. Frontiers in Human Neuroscience 2014 (8) 528.
  11. Improving working memory performance in brain-injured patients using hypnotic suggestion. (2017) Lindeløv J, Overgaard R & Overgaard M. Brain. Vol 140 (4) 1100- 1106.
  12. Acceptability and effectiveness of a strategy for the communication of the diagnosis of psychogenic nonepileptic seizures. (2010) Hall-Patch L, Brown R, House A, Howlett S, Kemp S, Lawton G, Mayor R, Smith P, Reuber M; NEST collaborators. Epilepsia. Vol 51(1) 70-8.

via Functional Strokes – Rehabilitation: Can hypnotic (and allied) techniques help? | ACNR | Online Neurology Journal

 

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[Abstract] Active exergames to improve cognitive functioning in neurological disabilities: a systematic review and meta-analysis

INTRODUCTION: Exergames represent a way to perform physical activity through active video games, serving as potentially useful tool in the field of neurorehabilitation. However, little is known regarding the possible role of exergames in improving cognitive functions in persons suffering from neurological disabilities.

 

EVIDENCE ACQUISITION: A search for relevant articles was carried out on PubMed/Medline, Scopus, PEDro, and Google Scholar. Only randomized controlled studies and non-randomized but controlled studies were retained. The following additional inclusion criteria were applied: studies focused on physical activity interventions carried out by means of exergames; populations targeted were affected by neurological disabilities; and reported results were related to cognitive outcomes. We calculated standardized mean differences (SMD) and pooled results using a random effects meta-analysis.

EVIDENCE SYNTHESIS: Of 520 abstracts screened, thirteen studies met the criteria to be included yielding a total of 465 participants, 233 randomized to exergames, and 232 allocated to the alternative or no intervention. The included studies varied in terms of studied populations (e.g., multiple sclerosis, post-stroke hemiparesis, Parkinson’s disease, dementia, dyslexia, Down syndrome), type and duration of interventions, and cognitive outcome measures. Exergames significantly improved executive functions (SMD=0.53, P=0.005; 8 studies, N.=380) and visuo-spatial perception (SMD=0.65, P<0.0001; 5 studies, N.=209) when compared to the alternative or no intervention. There were no significant differences for attention (SMD=0.57, P=0.07; 7 studies, N.=250) and global cognition (SMD=0.05, P=0.80; 6 studies, N.=161).

CONCLUSIONS: Exergames are a highly-flexible tool for rehabilitation of both cognitive and motor functions in adult populations suffering from various neurological disabilities and developmental neurological disorders. Additional high-quality clinical trials with larger samples and more specific cognitive outcomes are needed to corroborate these preliminary findings.

CLINICAL REHABILITATION IMPACT: Exergames could be considered either as a supplemental treatment to conventional rehabilitation, or as strategy to extend benefits of conventional programs at home.

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via Active exergames to improve cognitive functioning in neurological disabilities: a systematic review and meta-analysis – European Journal of Physical and Rehabilitation Medicine 2018 June;54(3):450-62 – Minerva Medica – Journals

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[VIDEO] Robotic Exoskeleton Helps People With Neurological Disorders – YouTube

This robotic exoskeleton helps people get their mobility back. Harmony, the robotic exoskeleton, can assist individuals who have had strokes or spinal injuries.

For more visit: https://reneu.robotics.utexas.edu/pro…

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[CORDIS] European stem cell consortium for neural cell replacement, reprogramming and functional brain repair – Projects and Results

From 2013-10-01 to 2017-09-30, closed project

Project details

Total cost: EUR 8 186 684,46

EU contribution: EUR 6 000 000

Coordinated in: Italy

Call for proposal:

FP7-HEALTH-2013-INNOVATION-1See other projects for this call

Funding scheme:

CP-FP – Small or medium-scale focused research project

via European Commission : CORDIS : Projects and Results : European stem cell consortium for neural cell replacement, reprogramming and functional brain repair

Objective

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[WEB SITE] Robot-Assisted Therapy: What Is Right for Your Clinic?

Published on 

One of the advantages of this gait training system is that it uses end-effector technology to assist patients in stepping, while a therapist provides manual facilitation. (Photo by Kevin Hentz)

by Rebecca Martin, OTR/L, OTD, and Dennis Tom-Wigfield, PT, DPT

Investment in therapeutic technologies spans a continuum from elastic bands that cost a few dollars to room-sized mobility and balance systems that require construction build-outs and additional staff. Inhabiting the middle to upper range of this continuum are robotic devices and associated technology, which have become increasingly popular. Though these advanced technologies deserve a thorough cost-benefit analysis and review of competing products prior to purchase, the payoff they may provide in outcomes and efficiency can make the investment well worth the effort.

Among the facility-based technologies that have grabbed recent headlines, robot-assisted therapy is one that may be attractive to healthcare organizations. Robot-assisted therapy is an efficacious method to remediate disability associated with a wide variety of neurological disorders, most notably stroke and spinal cord injury (SCI). Intensity and repetition has been repeatedly demonstrated to be necessary for central nervous system excitation and associated motor learning.1Massed practice, or high-volume repetition, has been shown to improve muscle strength and voluntary function.2 Robot-assisted therapy has the capacity to provide high numbers of specific movements with support or guidance as necessary, ensuring optimal conditions for motor learning and recovery of function.3 Changes can be observed in as little as 6 weeks and peak around 12 weeks of training.4

Nearly all robotic devices include some sort of computer interface, even a virtual reality component, providing the patient and therapist with real-time feedback to improve performance. Robotic devices also allow for quantitative monitoring; measuring changes in strength, range of motion, and trajectory; and illuminating patient engagement trends, time, and effort.3 As the body of literature expands and supports its use, patients are seeking clinics with these resources. Robotic technology has the potential to align patients’ interests in validated strategies with clinics’ interests in efficiency and payor-supported interventions. Clinics have an opportunity to improve patient outcomes and efficiency with which they reach those outcomes by investing in robotic devices. This investment is not trivial, however, and better understanding of the capacity and scope of different devices will help to make sure that everyone’s resources are utilized appropriately.

Assessment: Get the Complete Picture

Before it begins to investigate and trial devices, a clinic should do a careful self-assessment. Clinics should have a good understanding of their patient factors and needs: demographics, diagnoses, and payor mix. Equally important, clinics should have a good understanding of how much of their own resources—money, time, and space—they have to spend. Although money is often considered to be the limiting factor in the acquisition of technology, time and space deserve equal consideration. Nothing would be worse than investing in the perfect body weight support (BWS) gait trainer, only to find that your ceiling is too low to accommodate it. Similarly, clinics should anticipate that therapists will need time outside patient care to learn the devices and that efficiency will suffer in the early learning phase. Clinics will want to consider existing technology and therapist-driven interventions when deciding on their specific needs. Clinics would benefit from having a clear plan for acquisition and incorporation of robotic technology into existing practices. Acquiring too much technology too quickly is a sure way to reduce integration of devices and waste valuable resources.

 

Visit Site —> Robot-Assisted Therapy: What Is Right for Your Clinic? – Rehab Managment

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[Abstract] Active exergames to improve cognitive functioning in neurological disabilities: a systematic review and meta-analysis

INTRODUCTION: Exergames represent a way to perform physical activity through active video games, serving as potentially useful tool in the field of neurorehabilitation. However, little is known regarding the possible role of exergames in improving cognitive functions in persons suffering from neurological disabilities.
EVIDENCE ACQUISITION: A search for relevant articles was carried out on PubMed/Medline, Scopus, PEDro, and Google Scholar. Only randomized controlled studies and non-randomized but controlled studies were retained. The following additional inclusion criteria were applied: studies focused on physical activity interventions carried out by means of exergames; populations targeted were affected by neurological disabilities; and reported results were related to cognitive outcomes. We calculated standardized mean differences (SMD) and pooled results using a random effects meta-analysis.
EVIDENCE SYNTHESIS: Of 520 abstracts screened, thirteen studies met the criteria to be included yielding a total of 465 participants, 233 randomized to exergames, and 232 allocated to the alternative or no intervention. The included studies varied in terms of studied populations (e.g., multiple sclerosis, post-stroke hemiparesis, Parkinson’s disease, dementia, dyslexia, Down syndrome), type and duration of interventions, and cognitive outcome measures. Exergames significantly improved executive functions (SMD=0.53, p=0.005; 8 studies, n=380) and visuo-spatial perception (SMD=0.65, p<0.0001; 5 studies, n=209) when compared to the alternative or no intervention. There were no significant differences for attention (SMD=0.57, p=0.07; 7 studies, n=250) and global cognition (SMD=0.05, p=0.80; 6 studies, n=161).
CONCLUSIONS: Exergames are a highly-flexible tool for rehabilitation of both cognitive and motor functions in adult populations suffering from various neurological disabilities and developmental neurological disorders. Additional high-quality clinical trials with larger samples and more specific cognitive outcomes are needed to corroborate these preliminary findings.
CLINICAL REHABILITATION IMPACT: Exergames could be considered either as a supplemental treatment to conventional rehabilitation, or as strategy to extend benefits of conventional programs at home.

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via Active exergames to improve cognitive functioning in neurological disabilities: a systematic review and meta-analysis – European Journal of Physical and Rehabilitation Medicine 2017 Oct 25 – Minerva Medica – Journals

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[Proceedings] Proceedings of the Third Neurological Disorders Summit (NDS-2017) – Journal of Neurology & Experimental Neuroscience – PDF file

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[Abstract] Linking of the quality of life in neurological disorders (Neuro-QoL) to the international classification of functioning, disability and health

Abstract

Background

The quality of life in neurological disorders (Neuro-QoL) is a U.S. National Institutes of Health initiative that produced a set of self-report measures of physical, mental, and social health experienced by adults or children who have a neurological condition or disorder.

Objective

To describe the content of the Neuro-QoL at the item level using the World Health Organization’s international classification of functioning, disability and health (ICF).

Methods

We assessed the Neuro-QoL for its content coverage of functioning and disability relative to each of the four ICF domains (i.e., body functions, body structures, activities and participation, and environment). We used second-level ICF three-digit codes to classify items into categories within each ICF domain and computed the percentage of categories within each ICF domain that were represented in the Neuro-QoL items.

Results

All items of Neuro-QoL could be mapped to the ICF categories at the second-level classification codes. The activities and participation domain and the mental functions category of the body functions domain were the areas most often represented by Neuro-QoL. Neuro-QoL provides limited coverage of the environmental factors and body structure domains.

Conclusions

Neuro-QoL measures map well to the ICF. The Neuro-QoL–ICF-mapped items provide a blueprint for users to select appropriate measures in ICF-based measurement applications.

Source: Linking of the quality of life in neurological disorders (Neuro-QoL) to the international classification of functioning, disability and health | SpringerLink

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