Posts Tagged NIR
There is a notable lack of therapeutic alternatives for what is fast becoming a global epidemic of traumatic brain injury (TBI). Photobiomodulation (PBM) employs red or near-infrared (NIR) light (600–1100nm) to stimulate healing, protect tissue from dying, increase mitochondrial function, improve blood flow, and tissue oxygenation. PBM can also act to reduce swelling, increase antioxidants, decrease inflammation, protect against apoptosis, and modulate microglial activation state. All these mechanisms of action strongly suggest that PBM delivered to the head should be beneficial in cases of both acute and chronic TBI. Most reports have used NIR light either from lasers or from light-emitting diodes (LEDs). Many studies in small animal models of acute TBI have found positive effects on neurological function, learning and memory, and reduced inflammation and cell death in the brain. There is evidence that PBM can help the brain repair itself by stimulating neurogenesis, upregulating BDNF synthesis, and encouraging synaptogenesis. In healthy human volunteers (including students and healthy elderly women), PBM has been shown to increase regional cerebral blood flow, tissue oxygenation, and improve memory, mood, and cognitive function. Clinical studies have been conducted in patients suffering from the chronic effects of TBI. There have been reports showing improvement in executive function, working memory, and sleep. Functional magnetic resonance imaging has shown modulation of activation in intrinsic brain networks likely to be damaged in TBI (default mode network and salience network).
- animal studies,
- clinical trials,
- human studies,
- low-level laser therapy,
- traumatic brain injury
Study co-authors Theodore Henderson, MD, PhD from the Neuro-Laser Foundation and Dr Larry Morries and Paolo Cassano of Massachusetts General suggest that a specific high-powered, near infrared light (NIR) can possibly re-energize damaged brain cells after penetrating the skin and skull, per the release.
In their study, which occurred from 2011 to 2013, the research team administered 10 transcranial applications of high-power NIR over the course of 2 months to 10 study participants who were diagnosed with chronic mild-to-moderate TBI. Using a Class IV laser and pulsed light, each treatment took less than 60 minutes, the release explains.